This guidance is mainly intended to support primary health care professionals but should also be of value to those working in specialist lymphedema services. It has been produced by a consensus group (membership listed on page 11) with an annual literature review for new evidence. Disclaimer: These recommendations do not discuss how lymphedema interacts with other pathologies and only a few select medications are reviewed. These guidelines were recommended for a population that did not necessarily have chromosome abnormalities. Discuss treatment management and drug interactions with your physician.